Hemolytic uremic syndrome is a rare condition that primarily affects children under the age of 10. It is often characterized by:
Damage to the lining of blood vessel walls
Destruction of red blood cells
Most cases of HUS occur after an infection in the digestive tract caused by the E. coli bacterium, O157:H7, the most common type in the United States. Diarrhea and upper respiratory infections are the most common precipitating factors in contracting HUS. This type of E. coli can be found in undercooked meat and is one of the causes of restaurant-related food poisoning outbreaks. HUS is less common in adults, but may occur more often in pregnant women, women who have been taking oral contraceptives, and women who are postpartum or having obstetric complications.
The first stage of HUS frequently lasts from one to 15 days and may include gastrointestinal symptoms, such as:
Severe problems in the bowel and colon may develop in some cases. In these cases, even if the gastroenteritis has stopped, a child may still exhibit the following symptoms:
Small, unexplained bruises or small, clot-sized hemorrhages visible in the mucosal lining of the mouth
The child may produce little urine because damaged red blood cells and other factors may clog the tiny blood vessels in the kidneys or cause lesions in the kidneys, making the kidneys work harder to remove wastes and extra fluid from the blood.
The body's inability to rid itself of excess fluid and waste may, in turn, cause:
High blood pressure
Swelling of the hands and feet
Generalized fluid accumulation (edema)
The symptoms of HUS may resemble other conditions or medical problems. Consult a doctor for diagnosis.
There is no known treatment that can stop the progress of the syndrome once it has started. It is important for your doctor to distinguish this disease from a similar condition called thrombotic thrombocytopenic purpura, which does have a specific treatment.
A treatment regimen for HUS will be established by your doctor based on your individual condition. Most treatments are aimed at easing the immediate symptoms and signs of this disease and at preventing further complications. This may include any or all of the following:
Treatment of high blood pressure
Maintaining specific levels of fluids and salts
Most children with HUS recover fully. A few, however, will have lasting kidney damage.